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Purpose

We believe extreme longevity is due to specific genes which function to delay aging and prevent disease. The purpose of our research is to identify the genes/mutations associated with healthier aging; to understand the biological functions of these genes/mutations; and to develop therapies to replicate these preservative genetic activities in individuals who do not have the genetic profile for longevity.

Condition

Eligibility

Eligible Ages
Over 65 Years
Eligible Genders
All
Accepts Healthy Volunteers
Yes

Inclusion Criteria

  • Ashkenazi Jewish, age 95+, - Offspring of person age 95+, - Offspring of parents who died age 70 or younger.

Exclusion Criteria

  • Non-Ashkenazis

Study Design

Phase
Study Type
Observational
Observational Model
Case-Control
Time Perspective
Prospective

Arm Groups

ArmDescriptionAssigned Intervention
Probands Ashkenazi Jews ages 95 and older
Offspring Ashkenazi Jewish offspring of Ashkenazi Jewish parent(s) who lived to at least the age of 95
Controls Ashkenazi Jewish people with no family history of longevity

Recruiting Locations

Boston University Medical Center
Boston, Massachusetts 02118-2526
Contact:
Thomas Perls, MD, MPH
617-638-7207

More Details

Status
Recruiting
Sponsor
Albert Einstein College of Medicine

Study Contact

Deborah Davidson, MBA
718-430-3237
longevity@aecom.yu.edu

Notice

Study information shown on this site is derived from ClinicalTrials.gov (a public registry operated by the National Institutes of Health). The listing of studies provided is not certain to be all studies for which you might be eligible. Furthermore, study eligibility requirements can be difficult to understand and may change over time, so it is wise to speak with your medical care provider and individual research study teams when making decisions related to participation.