Purpose

Multi-center observational study to evaluate the histopathology and transcriptome of cutaneous lesions in patients with several different types of vasculitis.

Conditions

Eligibility

Eligible Ages
Over 5 Years
Eligible Genders
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • Have a cutaneous lesion (purpuric macules, palpable purpura, retiform purpura, nodules, ulcers, or urticarial) believed to be related to active vasculitis - Have a suspected or confirmed diagnosis of: - Cryoglobulinemic vasculitis (CV) - Drug-induced vasculitis - Eosinophilic granulomatosis with polyangiitis (EGPA) - IgA vasculitis - Isolated cutaneous vasculitis - Granulomatosis with polyangiitis (GPA) - Microscopic polyangiitis (MPA) - Polyarteritis nodosa (PAN) - Urticarial vasculitis - Be willing and able to provide written informed consent (or assent for those under

Exclusion Criteria

  • You are less than five years old - Considered not to be a candidate for a biopsy or have a higher risk of developing an infection, bleeding, etc., from the biopsy, or a doctor believes that the risks for you participating in this study do not outweigh the potential benefit of learning information from your biopsy - You have a neutrophil count (type of white blood cell) less than 1500/mm3, platelet count less than 50,000/mm3, or a hemoglobin less than 7 g/dL - You have an uncontrolled disease that could prevent you from completing the study procedures - You have an active infection at or near the potential biopsy site, have poor circulation, or have bony prominence or other structure that would increase your risk of complications if you participated in this study - You are pregnant or nursing - You are not able to provide informed consent

Study Design

Phase
Study Type
Observational
Observational Model
Cohort
Time Perspective
Prospective

Recruiting Locations

More Details

Status
Recruiting
Sponsor
Peter Merkel

Study Contact

Carol McAlear, MA
cmcalear@upenn.edu

Detailed Description

This study employs a multi-center approach to evaluate cutaneous vasculitis across several forms of idiopathic vasculitis. Patients with cutaneous manifestations of vasculitis will be evaluated by teams of primary vasculitis care providers and Dermatologists in order to facilitate optimal selection of patients and sampling of lesions. A punch skin biopsy at a site of active vasculitis will be the source of material for histopathologic and transcriptomic evaluation. The histopathology of cutaneous vasculitis will be characterized using a standardized approach.

Notice

Study information shown on this site is derived from ClinicalTrials.gov (a public registry operated by the National Institutes of Health). The listing of studies provided is not certain to be all studies for which you might be eligible. Furthermore, study eligibility requirements can be difficult to understand and may change over time, so it is wise to speak with your medical care provider and individual research study teams when making decisions related to participation.