Purpose

This phase III ALCHEMIST trial studies how well erlotinib hydrochloride compared to observation works in treating patients with stage IB-IIIA non-small cell lung cancer that has been completely removed by surgery. Erlotinib hydrochloride may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.

Conditions

Eligibility

Eligible Ages
Over 18 Years
Eligible Genders
All
Accepts Healthy Volunteers
No

Criteria


Inclusion Criteria:

- Previously registered to A151216, with the result of lung cancer harboring an EGFR
exon 19 deletion or L858R mutation; the testing must have been performed by one of the
following criteria:

1. Patient registered to A151216 and the assessment performed centrally by the
protocol-specified laboratory

2. By a local Clinical Laboratory Improvement Amendments (CLIA) certified
laboratory; the report must indicate the result as well as the CLIA number of the
laboratory that performed the assay; these patients will also have been
registered to A151216, but can be enrolled on A081105 regardless of the central
lab results

- Patients with known resistant mutations in the EGFR tyrosine-kinase (TK)
domain (T790M) are not eligible

- Patients that are both EGFR mutant and anaplastic lymphoma kinase (ALK)
rearrangements will be registered to A081105

- Completely resected stage IB (>= 4 cm), II or IIIA non-squamous NSCLC with negative
margins; patients may not have received neoadjuvant therapy (chemo- or radio-therapy)
for this lung cancer

- Complete recovery from surgery and standard post-operative therapy (if required);
patients must be completely recovered from surgery at the time of randomization; the
minimum time requirement between date of surgery and randomization must be at least 28
days, the maximum time requirement between surgery and randomization must be 90 days
if no adjuvant chemotherapy was administered, 240 days if adjuvant chemotherapy was
administered, and 300 days if adjuvant chemotherapy and radiation therapy was
administered

- Eastern Cooperative Oncology Group (ECOG) performance status 0-1

- No locally advanced or metastatic cancer requiring systemic therapy within 5 years
prior to registration; no secondary primary lung cancer diagnosed concurrently or
within 2 years prior to registration

- Non-pregnant and non-lactating

- No history of cornea abnormalities

- Granulocytes >= 1,500/ul

- Platelets >= 100,000/ul

- Total bilirubin =< 1.5 x upper limit of normal (ULN)

- Serum glutamic oxaloacetic transaminase (SGOT) =< 1.5 x ULN

- Serum creatinine =< 1.5 x ULN

Study Design

Phase
Phase 3
Study Type
Interventional
Allocation
Randomized
Intervention Model
Parallel Assignment
Primary Purpose
Treatment
Masking
None (Open Label)
Masking Description
As of June 15, 2017, sites will sign into RAVE to unblind any patients that had previously enrolled

Arm Groups

ArmDescriptionAssigned Intervention
Experimental
Arm A (blinded erlotinib hydrochloride)
Blinded patients receive erlotinib hydrochloride PO QD on days 1-21. Treatment repeats every 21 days for up to 2 years in the absence of disease progression or unacceptable toxicity. (CLOSED 06/14/17)
  • Drug: Erlotinib Hydrochloride
    Given PO
    Other names:
    • Cp-358,774
    • OSI-774
    • Tarceva
  • Other: Laboratory Biomarker Analysis
    Correlative studies
Placebo Comparator
Arm B (placebo)
Patients receive placebo PO QD on days 1-21. Treatment repeats every 21 days for up to 2 years in the absence of disease progression or unacceptable toxicity. (CLOSED 06/14/17)
  • Other: Laboratory Biomarker Analysis
    Correlative studies
  • Other: Placebo Administration
    Given PO
Experimental
Arm C (unblinded erlotinib hydrochloride)
Unblinded patients receive erlotinib hydrochloride PO QD on days 1-21. Treatment repeats every 21 days for up to 2 years in the absence of disease progression or unacceptable toxicity.
  • Drug: Erlotinib Hydrochloride
    Given PO
    Other names:
    • Cp-358,774
    • OSI-774
    • Tarceva
  • Other: Laboratory Biomarker Analysis
    Correlative studies
Active Comparator
Arm D (observation)
Patients (including patients previously randomized to placebo) undergo observation at least every 6 months for 2 years.
  • Other: Clinical Observation
    Undergo observation
    Other names:
    • observation
  • Other: Laboratory Biomarker Analysis
    Correlative studies

Recruiting Locations

Boston Medical Center
Boston, Massachusetts 02118
Contact:
Site Public Contact
617-638-8265

More Details

Status
Recruiting
Sponsor
National Cancer Institute (NCI)

Study Contact

Detailed Description

PRIMARY OBJECTIVE:

I. To assess whether adjuvant therapy with erlotinib hydrochloride (erlotinib) will result in improved overall survival (OS) over observation for patients with completely resected stage IB (>= 4 cm)-IIIA epidermal growth factor receptor (EGFR) mutant non-small cell lung cancer (NSCLC) (confirmed centrally) following complete resection and standard post-operative therapy.

SECONDARY OBJECTIVES:

I. To assess whether adjuvant therapy with erlotinib will result in improved disease free survival (DFS) over observation for patients with completely resected stage IB (>= 4 cm)-IIIA EGFR mutant NSCLC (confirmed centrally) following complete resection and standard post-operative therapy, both overall and within the stage subgroups: IB and II/IIIA.

II. To evaluate the safety profile of erlotinib in the adjuvant setting. III. To assess whether adjuvant therapy with erlotinib will result in improved DFS rate at 2 years, and OS rate at 5 and 10 years over observation for patients with completely resected stage IB (>= 4 cm)-IIIA EGFR mutant NSCLC (confirmed centrally) following complete resection and standard post-operative therapy, both overall and within the stage subgroups: IB and II/IIIA.

IV. To assess the primary and secondary objectives in all randomized patients, regardless of central confirmation of the EGFR mutant status.

V. To study detection of circulating EGFR mutations in cell-free plasma deoxyribonucleic acid (DNA) as a prognostic marker in resected early stage NSCLC.

OUTLINE: Patients are randomized to 1 of 4 treatment arms.

ARM A (BLINDED ERLOTINIB- CLOSED 06/14/17): Blinded patients receive erlotinib hydrochloride orally (PO) once daily (QD) on days 1-21. Treatment repeats every 21 days for up to 2 years in the absence of disease progression or unacceptable toxicity.

ARM B (PLACEBO- CLOSED 06/14/17): Patients receive placebo PO QD on days 1-21. Treatment repeats every 21 days for up to 2 years in the absence of disease progression or unacceptable toxicity.

ARM C (UNBLINDED ERLOTINIB): Unblinded patients receive erlotinib hydrochloride PO QD on days 1-21. Treatment repeats every 21 days for up to 2 years in the absence of disease progression or unacceptable toxicity.

ARM D (OBSERVATION): Patients (including patients previously randomized to placebo) undergo observation at least every 6 months for 2 years.

After completion of study treatment, patients are followed up every 6 months for 4 years and then yearly for 6 years.

Notice

Study information shown on this site is derived from ClinicalTrials.gov (a public registry operated by the National Institutes of Health). The listing of studies provided is not certain to be all studies for which you might be eligible. Furthermore, study eligibility requirements can be difficult to understand and may change over time, so it is wise to speak with your medical care provider and individual research study teams when making decisions related to participation.