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Effects of Nitric Oxide on the Endothelium During Hemolysis.
Massachusetts General Hospital
Endothelial Dysfunction
Hemolysis Intravascular
Cardiovascular Diseases
Cardiovascular Risk Factor
This study is an ancillary (add-on) study to the clinical trial entitled "Effect of
Nitric Oxide in Cardiac Surgery Patients With Endothelial Dysfunction", which has
Clinical Trials.gov identifier NCT02836899. NCT02836899 trial randomizes cardiac surgical
patients to receive either Nitric Oxide (NO)... expand
This study is an ancillary (add-on) study to the clinical trial entitled "Effect of Nitric Oxide in Cardiac Surgery Patients With Endothelial Dysfunction", which has Clinical Trials.gov identifier NCT02836899. NCT02836899 trial randomizes cardiac surgical patients to receive either Nitric Oxide (NO) or a placebo during and after cardiac surgery. This ancillary study aims to assess the effects of Nitric Oxide on vascular responsiveness and on endothelial function during hemolysis in patients with pre-operative endothelial dysfunction undergoing cardiac surgery requiring prolonged cardiopulmonary bypass. Type: Interventional Start Date: Dec 2018 |
Renal Mechanism of SGLT2 Inhibition
University of Colorado, Denver
Type 2 Diabetes
Diabetic Kidney Disease
Canagliflozin is an oral drug which is currently approved for use in patients with type 2
diabetes by the US Food and Drug Administration (FDA). Canagliflozin acts by increasing
salt and sugar loss in the urine, and has shown to protect heart, kidney, and blood
vessel function in patients with type... expand
Canagliflozin is an oral drug which is currently approved for use in patients with type 2 diabetes by the US Food and Drug Administration (FDA). Canagliflozin acts by increasing salt and sugar loss in the urine, and has shown to protect heart, kidney, and blood vessel function in patients with type 2 diabetes. However, it is unknown how canagliflozin protects the kidneys from disease. Therefore, this study plans to learn more about how canagliflozin works to protect against diabetic kidney disease in adults with type 2 diabetes. This study will use state-of-the-art kidney imaging, kidney biopsies and detailed testing of kidney function to determine the mechanisms of protection afforded by canagliflozin. Type: Interventional Start Date: Oct 2022 |
Parents Advancing Toddler Health
Boston University Charles River Campus
Sleep Problem
Behavior, Child
Although early interventions can improve health equity in young children living in
poverty, this promise often is not realized because of barriers to family engagement. The
proposed study will target co-morbid behavior and sleep problems in early childhood,
comparing child outcomes and family response... expand
Although early interventions can improve health equity in young children living in poverty, this promise often is not realized because of barriers to family engagement. The proposed study will target co-morbid behavior and sleep problems in early childhood, comparing child outcomes and family response to sleep and behavior interventions and investigating the novel strategy of letting families select their intervention.We will enroll 500 low-income toddlers with co-morbid sleep and behavior problems, randomized to 4 parent coaching interventions: sleep, behavior, family choice (sleep or behavior), and an active control. At baseline and at 1, 5, and 9 months post- intervention, we will assess child sleep and behavior and family functioning. We will measure family preference, engagement, and perceived value of each intervention. The goals of the study are: (1) to examine effects of evidence- based sleep and behavior interventions in young low-income children with co-morbid sleep and behavior problems on child sleep and behavior and family functioning; (2) to determine whether parents prefer, engage with, and value a sleep or behavior intervention more; and (3) to examine if giving families a choice of intervention results in higher engagement, higher perceived value and better family and child outcomes than assignment to intervention. By informing best practices for engaging low-income families to treat co-morbid sleep and behavior problems, results will be critical to reducing health disparities for children living in poverty. Type: Interventional Start Date: Mar 2021 |
Study on the Compensatory Mechanism of Iodine Nutrition and the Optimal Intake Level of Lactating Women
Tianjin Medical University
Nutritional Requirements
Due to the lack of direct evidence of optimal iodine intake of Chinese children, pregnant
and lactating women and infants were found during the recent revision of Chinese dietary
reference intakes (DRIs) of iodine in 2013 by the applicant Pro. Zhang, and no
systematical research about compensatory... expand
Due to the lack of direct evidence of optimal iodine intake of Chinese children, pregnant and lactating women and infants were found during the recent revision of Chinese dietary reference intakes (DRIs) of iodine in 2013 by the applicant Pro. Zhang, and no systematical research about compensatory mechanism of iodine nutrition in lactating women was found yet. Previous study funded by United Nations International Children's Emergency Fund (UNICEF) cooperated with the international experts on iodine and key project of national natural science foundation of China under the guidance of Pro. Zhang, had obtained the safe intake range of iodine from children and pregnant women, more than 10 joint papers were published, which laid the foundation of population study and international cooperation. Type: Observational Start Date: Jan 2020 |
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